In Calvinism more than in any other form of Protestantism the message of Christianity is clearly presented as a challenge to the wisdom of the world. The natural man must not be encouraged to think that he can, in terms of his own adopted principles, find truth in any field. He must rather be told that, when he finds truth, even in the realm of the “phenomenal,” he finds it in terms of principles that he has “borrowed,” wittingly or unwittingly, from Christianity. The fact of science and its progress is inexplicable except upon the presupposition that the world is made and controlled by God through Christ and that man is made and renewed in the image of God through Christ.
– Cornelius Van Til, The Case for Calvinism p.106-107